CRACKLE: Carbapenems in Klebsiella pneumoniae and Other Enterobacteriaceae

The Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE) is a federally funded, prospective multi-center consortium to track carbapenem-resistant Enterobacteriacea. As part of this program strains and associated clinical data are being collected to investigate the association of various carbapenem-resistant Klebsiella pneumoniae (CRKp) clades with clinical and genomic features. The Antibiotic Resistance Leadership Group (ARLG) has contributed additional funding to obtain minimum inhibitory concentration (MIC) data and very limited molecular characterization for CRACKLE strains.

The overarching hypothesis of the CRACKLE program is that certain CRKP clades belonging to the ST258 sequence type carry specific genes that impact clinical outcomes and that these genetic elements are non-uniformly distributed among ST258 strains. Genome sequencing and analysis under this supplement will augment the existing CRACKLE and ARLG funded study of CRACKLE strains.

Funding