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Characterization of Burkholderia Persistence Determinants and Antibiotic Resistance
Melioidosis, a serious disease endemic to tropical regions of Southeast Asia, northern Australia, Africa, the Middle East, China, India, and South America is caused by the motile Gram-negative bacterium, Burkholderia pseudomallei (Bp). Bp is intrinsically resistant to many antibiotics. Additionally, surviving a melioidosis infection confers no immunity to subsequent challenge with Bp nor are there vaccines that are protective against melioidosis. A major concern in the management of...
New wiki on salivary proteins may transform diagnostic testing and personalized medicine
A diagram that shows the interconnectedness of the thousands of salivary proteins originating from blood plasma, parotid glands, and submandibular and sublingual glands. The diagram is one of many tools available to researchers and clinicians through the Human Salivary Proteome Wiki. By Marcene Robinson BUFFALO, N.Y. – To improve the development of new saliva-based diagnostic tests and personalized medicine, the National Institute of Dental and Craniofacial Research...
Research Impact: Accelerating Efforts to Contain and Prevent the Zika Virus (ZIKV)
The rapidly developing Zika virus (ZIKV) outbreak has research groups, government agencies, and industry is all striving to develop a response plan to contain and ultimately prevent ZIKV spread. Currently JCVI is working with both private and public sector funders to sequence and analyze historical and current ZIKV strains. Work at JCVI is geared toward developing sensitive ZIKV diagnostics, significantly increasing the number of ZIKV genomic sequences available, and performing cutting-edge...
Gordon and Betty Moore Foundation identifies 16 leading scientists to pursue high-risk research in marine microbial ecology
Palo Alto, Calif. — The Gordon and Betty Moore Foundation announced its Marine Microbiology Initiative investigator awards today, providing 16 scientists from 14 different institutions a total of up to $35 million over five years to pursue pioneering research in the field of marine microbial ecology. The funding will enable researchers to explore how the trillions upon trillions of microscopic organisms at the base of the ocean’s food webs interact with each other and...
U.S. / African Project Deciphers Deadly Parasite Genome
June 30, 2005 Rockville, MD, and Nairobi, Kenya — An innovative North-South research collaboration has culminated in a study published in this week's Science that provides molecular clues to help develop new ways to treat or prevent East Coast fever. The disease, which kills a million cattle a year in East and Central Africa, has had a devastating impact on rural areas — such as Maasai tribal communities in Kenya — where cattle play a crucial role in the local society...
Sampling in Helgoland — A warm German welcome for the Sorcerer II
After a little more than two weeks in Plymouth, UK the Sorcerer II set sail on June 3rd. We were sad to say goodbye to our new friends at PLM, but we were grateful for their hospitality, friendship and scientific collaboration. We're looking forward to coming back through Plymouth in the fall. We motor sailed in calm weather but with all the other boat traffic in the English Channel we were on constant watch. On June 6th we arrived on Helgoland, an island about 70 kilometers from the...
Surprising Symbiosis: Glassy-Winged Sharpshooter Eats With Friends
June 5, 2006 Like a celebrity living on mineral water, the glassy-winged sharpshooter consumes only the dilute sap of woody plants — including grapevines in California , which is feverishly working to prevent the insect's flight into prized vineyards. Now, in a surprising study published in the June 6 issue of Public Library of Science Biology (PLoS Biology), researchers at The Institute for Genomic Research (TIGR), the University of Arizona , and their colleagues have discovered...
SOS: Saving Our
Oceans with Science
h4[data-toggle="collapse"] img { height: 33px; transition: .33s; } h4[data-toggle="collapse"]:not(.collapsed) img { transform: scaleY(-1); } Donate now — we need your support When you live in San Diego and other coastal communities, the beauty and many benefits of the ocean are a daily part of our lives. Although our oceans have proven somewhat resilient to many threats, their ability to bounce back cannot be taken for granted. Increasing temperatures,...
Past encounters with the flu shape vaccine response
UNIVERSITY OF CHICAGO MEDICAL CENTER New research on why the influenza vaccine was only modestly effective in recent years shows that immune history with the flu influences a person's response to the vaccine. Low effectiveness of the flu vaccine is often blamed on problems with how the vaccine is designed and produced. Sometimes the flu strains chosen for the vaccine are a poor match for those that end up circulating in the public, especially in years when the H3N2 strain...
Genomics-Based Vaccine Could Prevent Deadly Cattle Disease
February 13, 2006 Every year, East Coast fever destroys the small farmer's dream of escaping poverty in Africa. Killing more than a million cattle and costing some $200 million annually, this tick-borne disease rages across a dozen countries in eastern and central Africa. Now, an international team of scientists has taken the first major step toward a vaccine to prevent East Coast fever. Their work, published in the February 13-17 early online edition of the Proceedings of the National...