Search
Genomics of the Indoor Air Environment
Most of our life is spent in indoors, well-buffered from the constant changes in temperature, humidity, wind and light which shape life outside our homes and offices. It seems intuitive that the types of microorganisms which inhabit our indoor environment must be different from those on the outside; after all, by removing environmental stresses such as UV, dessication and wind, we eliminate selective pressures on populations.We spend 23 hours a day indoors, but we know very little about...
Study reveals mouth as primary source of COVID-19 infection, spread
(CHAPEL HILL, N.C.) A first-of-its-kind study shows the mouth is a robust site for infection and transmission of COVID-19, according to new research published Oct. 27 on the preprint server medRxiv. A team of researchers led by the University of North Carolina at Chapel Hill and the National Institute of Dental and Craniofacial Research reveals coronavirus can take hold in the salivary glands where it replicates, and in some cases, leads to prolonged disease when infected saliva is...
Proteogenomic analysis of bacteria and archaea: a 46 organism case study.
Experimental evidence is increasingly being used to reassess the quality and accuracy of genome annotation. Proteomics data used for this purpose, called proteogenomics, can alleviate many of the problematic areas of genome annotation, e.g. short protein validation and start site assignment. We performed a proteogenomic analysis of 46 genomes spanning eight bacterial and archaeal phyla across the tree of life. These diverse datasets facilitated the development of a robust approach for...
Characterization of Prochlorococcus clades from iron-depleted oceanic regions.
Prochlorococcus describes a diverse and abundant genus of marine photosynthetic microbes. It is primarily found in oligotrophic waters across the globe and plays a crucial role in energy and nutrient cycling in the ocean ecosystem. The abundance, global distribution, and availability of isolates make Prochlorococcus a model system for understanding marine microbial diversity and biogeochemical cycling. Analysis of 73 metagenomic samples from the Global Ocean Sampling expedition acquired in...
TIGR and Multinational Consortia Announce Sequencing Results of First Genome of A Higher Plant
December 08, 2000 ROCKVILLE, MD - Researchers at The Institute for Genomic Research (TIGR) together with two other teams of scientists join the National Science Foundation today in announcing their contributions to the Arabidopsis Genome Initiative (AGI), a multinational consortium of sequencing centers from the United States, Europe and Japan, which was created in 1996 to ensure timely completion of DNA sequencing of the five chromosomes constituting the Arabidopsis thaliana genome....
S2 Genomics Awarded $280,000 Phase I STTR Grant from the National Institutes of Health
LIVERMORE, CA – June 26, 2018 – S2 Genomics, Inc. has received a $280,000 Phase I STTR grant (1 R41 HG010129-01) from the National Institutes of Health’s National Human Genome Research Institute to develop the Singulator™ system for automated preparation of single cells or single nuclei suspensions from solid tissue samples. The system will include single-use sample cartridges and proprietary reagents that allow researchers to isolate cells or nuclei rapidly,...
DNA repeats identify novel virulence genes in Haemophilus influenzae.
The whole genome sequence (1.83 Mbp) of Haemophilus influenzae strain Rd was searched to identify tandem oligonucleotide repeat sequences. Loss or gain of one or more nucleotide repeats through a recombination-independent slippage mechanism is known to mediate phase variation of surface molecules of pathogenic bacteria, including H. influenzae. This facilitates evasion of host defenses and adaptation to the varying microenvironments of the host. We reasoned that iterative nucleotides could...
Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.
Arabidopsis thaliana (Arabidopsis) is unique among plant model organisms in having a small genome (130-140 Mb), excellent physical and genetic maps, and little repetitive DNA. Here we report the sequence of chromosome 2 from the Columbia ecotype in two gap-free assemblies (contigs) of 3.6 and 16 megabases (Mb). The latter represents the longest published stretch of uninterrupted DNA sequence assembled from any organism to date. Chromosome 2 represents 15% of the genome and encodes 4,037...
Scientists Decipher Genetic Code of Malaria Parasite
October 2, 2002 Rockville, MD - In a landmark contribution to the age-old battle against malaria, a consortium of scientists including The Institute for Genomic Research (TIGR) announced today that they have deciphered the complex genetic code of the parasite that causes the deadliest form of the disease. Malaria is one of the world's most devastating infectious diseases, killing more than a million people a year in developing nations. The scientific paper analyzing the genome of that...
Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.
Virulence and immunity are poorly understood in Mycobacterium tuberculosis. We sequenced the complete genome of the M. tuberculosis clinical strain CDC1551 and performed a whole-genome comparison with the laboratory strain H37Rv in order to identify polymorphic sequences with potential relevance to disease pathogenesis, immunity, and evolution. We found large-sequence and single-nucleotide polymorphisms in numerous genes. Polymorphic loci included a phospholipase C, a membrane lipoprotein,...