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LJI Scientists Identify Potential Targets for Immune Responses to Novel Coronavirus
LA JOLLA, CA—Within two months, SARS-CoV-2, a previously unknown coronavirus, has raced around globe, infecting over a 100,000 people with numbers continuing to rise quickly. Effective countermeasures require helpful tools to monitor viral spread and understand how the immune system responds to the virus. Publishing in the March 16, 2020, online issue of Host, Cell and Microbe, a team of researchers at La Jolla Institute for Immunology, in collaboration with researchers at the J....
Evolution of allostery in the cyclic nucleotide binding module.
The cyclic nucleotide binding (CNB) domain regulates signaling pathways in both eukaryotes and prokaryotes. In this study, we analyze the evolutionary information embedded in genomic sequences to explore the diversity of signaling through the CNB domain and also how the CNB domain elicits a cellular response upon binding to cAMP.
The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium.
The complete genome of the green-sulfur eubacterium Chlorobium tepidum TLS was determined to be a single circular chromosome of 2,154,946 bp. This represents the first genome sequence from the phylum Chlorobia, whose members perform anoxygenic photosynthesis by the reductive tricarboxylic acid cycle. Genome comparisons have identified genes in C. tepidum that are highly conserved among photosynthetic species. Many of these have no assigned function and may play novel roles in photosynthesis...
About Sanjay Vashee
Sanjay Vashee is a professor in the Synthetic Biology Group and the Rockville, MD Campus Director at the J. Craig Venter Institute. After joining JCVI in 2003, Dr. Vashee helped the Synthetic Biology Group develop synthetic genomics methods and technologies that led to the creation of a synthetic organism based on Mycoplasma mycoides subspecies capri.
E-CELL: software environment for whole-cell simulation.
Genome sequencing projects and further systematic functional analyses of complete gene sets are producing an unprecedented mass of molecular information for a wide range of model organisms. This provides us with a detailed account of the cell with which we may begin to build models for simulating intracellular molecular processes to predict the dynamic behavior of living cells. Previous work in biochemical and genetic simulation has isolated well-characterized pathways for detailed...
About Hyesun “Sunny” Jang
Hyesun “Sunny” Jang is a staff scientist at the J. Craig Venter Institute, supervised by Dr. Marcelo Freire. With a background as a veterinarian, Dr. Jang is interested in developing host-directed anti-viral strategies against diverse zoonotic viruses.
Fighting Back Against Flu
The 1918 influenza pandemic, which affected 500 million people globally and caused 50-100 million deaths, was the most severe pandemic in recorded history. Over the course of the last 100 years, advances in science and medicine have provided the tools to address influenza much more successfully. However, despite vaccines and supportive medical interventions such as antivirals and antibiotics, influenza remains a public health problem and can be deadly for the very young, the elderly, and...