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Identifying Bacterial Antibiotic Resistance Markers in gut microbes
Ian Lamb, Manolito Torralba J. Craig Venter Institute, La Jolla, CA The gut microbiome plays a critical role in our health and well-being, but it also facilitates sharing of antibiotic resistance genes. However, antibiotic resistance genes can be identified by distinct markers which we screen in this study. Plasmids pTRACA18, pTRACA20, and pTRACA22 were chosen since they have demonstrated to be present in many gut microbes. This in turn allows the bacteria to spread...
About Anders M. Dale
Anders Dale, Ph.D., is president, faculty, and board member of the J. Craig Venter Institute (JCVI). Prior to joining JCVI, Dr. Dale was Professor of neurosciences, radiology, and data science at the University of California San Diego. He has also founded and led several AI-focused biotech startups. They include Cortechs.ai, Precision-Health.ai, and Precision-Pro.ai.
Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease.
The presenilin 1 gene has recently been identified as the locus on chromosome 14 which is responsible for a large proportion of early onset, autosomal dominantly inherited Alzheimer's disease (AD). We have elucidated the intron/exon structure of the gene and designed intronic primers to enable direct sequencing of the entire coding region (10 exons) of the presenilin gene in a large number of families. This strategy has enabled us to find a further two novel mutations in the gene. We...
JCVI to Receive Grant from Chan Zuckerberg Initiative to Define the Language of Human Cell Classification
Researchers at J. Craig Venter Institute (JCVI), led by Richard Scheuermann, PhD, director of JCVI’s La Jolla Campus, have been awarded a grant from the Chan Zuckerberg Initiative DAF, an advised fund of Silicon Valley Community Foundation as part of the Human Cell Atlas project. JCVI will be building on our previous work in developing an expanded human cell ontology that scientists can use to classify cells and effectively communicate among one another. On average there are around 30...
Influences of trace metals on biological evolution
Scientists show how trace metal chemistry and global changes in oxygen have influenced the evolution of metalloproteins and the Eukaryotes A paper is being published in PNAS this week about how the varying abundance of trace metals in the environment has influenced biological evolution. The research team, led by Chris Dupont of the J. Craig Venter Institute and Gustavo Caetano-Anollés at the University of Illinois, correlated environmental changes in metal availability over the...
The NIAID Sponsored Pathogen Functional Genomics Resource Center Announces a Call for White Papers in Functional Genomics and Proteomics
The National Institute of Allergy and Infectious Diseases (NIAID)/NIH/DHHS Pathogen Functional Genomics Resource Center (PFGRC) at the J. Craig Venter Institute (JCVI) is announcing a call for White Papers in the areas of Gene Expression studies, Comparative Genomics, Gene Knock Outs, Proteomics and Bioinformatics as well as associated methodologies and technologies. It is our desire to continue to identify the most relevant resources and collaborative opportunities between the scientific...
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cDNA sequencing: a means of understanding cellular physiology.
High-throughput automated sequencing has enabled researchers to examine large numbers of clones from a cDNA library as a measure of the steady-state levels of mRNA species. The past year has witnessed many new applications of this technique to allow the qualitative and quantitative comparison of the changes in transcript levels from multiple genes.
Newly Discovered Human Brain Cell: Rosehip Neurons
What’s next for exploring the newly discovered human brain cell, the rose hip neuron? We caught up with Dr. Richard Scheuermann on the road to discuss how the J. Craig Venter Institute is advancing knowledge about what makes humans unique. See the full press release.