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The JCVI Genomic Frontier Fund
As we complete our 26th year as a private genomic research institution, we are still just as excited as we were in the very beginning to be making new discoveries, potentially ones that will change our society for the better. The knowledge gained from our study of DNA, or as Dr. Venter likes to call it, “the software of life”, has exponentially accelerated the progress of science and medicine. However, we are still just scratching the surface of understanding life and many more...
Summer 2016 Intern Program
Interns in both Rockville, MD and La Jolla, CA participated in our summer 2016 internship program at the J. Craig Venter Institute (JCVI). A total of 19 interns were hired for the summer 2016 program, selected from 578 applicants. Of the 19 interns, six interns were part of the Genomic Scholar Program (GSP) that is a transition program focusing on the leap from a community college to a four-year college using a combination of activities including undergraduate research experience with...
The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families.
Genetic linkage studies place a gene causing early onset familial Alzheimer's disease (FAD) on chromosome 14q24.3 (refs 1-4). Five mutations within the S182 (Presenilin 1: PS-1) gene, which maps to this region, have recently been reported in several early onset FAD kindreds. We have localized the PS-1 gene to a 75 kb region and present the structure of this gene, evidence for alternative splicing and describe six novel mutations in early onset FAD pedigrees all of which alter residues...
JCVI La Jolla Directions
J. Craig Venter Institute 4120 Capricorn Lane La Jolla, CA 92037 Phone: 858-200-1800 Driving Directions From the South on I-5 (from San Diego Airport) Take the La Jolla Village Drive exitTurn left onto La Jolla Village Drive Stay in left-most non-turn lane Enter left turn lane after Torrey Pines Road intersection Turn left onto Expedition Way Immediate first left is Capricorn Lane Continue to JCVI building From the North on I-5 (from...
LJI Scientists Identify Potential Targets for Immune Responses to Novel Coronavirus
LA JOLLA, CA—Within two months, SARS-CoV-2, a previously unknown coronavirus, has raced around globe, infecting over a 100,000 people with numbers continuing to rise quickly. Effective countermeasures require helpful tools to monitor viral spread and understand how the immune system responds to the virus. Publishing in the March 16, 2020, online issue of Host, Cell and Microbe, a team of researchers at La Jolla Institute for Immunology, in collaboration with researchers at the J....
How many genes in the human genome?
Generating a Library of Influenza a Virus Hemagglutanin and Neuraminidase Genes
Titas Bera, Anthony Bennici, Haley Hochstein, Karla M. Stucker, Suman R. Das, David E. Wentworth Virology Group, J. Craig Venter Institute, Rockville, MD 20850 Every year, five to twenty percent of the United States population is infected with seasonal influenza, making the construction of a seasonal vaccine of high importance. However, due to antigenic drift among seasonal influenza viruses, the vaccine strains need frequent updating. Antigenic drift occurs as the genes...
Sequence identification of 2,375 human brain genes.
We recently described a new approach for the rapid characterization of expressed genes by partial DNA sequencing to generate 'expressed sequence tags'. From a set of 600 human brain complementary DNA clones, 348 were informative nuclear-encoded messenger RNAs. We have now partially sequenced 2,672 new, independent cDNA clones isolated from four human brain cDNA libraries to generate 2,375 expressed sequence tags to nuclear-encoded genes. These sequences, together with 348 brain expressed...
Potential Breakthroughs in Treating Oral Disease Through Better Understanding of the Oral Microbiome
Most people think of bacteria as the enemy, but scientists at the J. Craig Venter Institute (JCVI) are exploring ways to harness bacteria and phages (the viruses that infect bacteria) as a new way to fight infection. JCVI scientist, Anna Edlund, PhD, is leading one of our efforts to understand the human oral microbiome and learn what role bacteria play in both oral health and disease. Inflammatory gum disease (gingivitis/periodontal disease) and tooth decay are not only the two...