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Towards a comprehensive structural variation map of an individual human genome.
Several genomes have now been sequenced, with millions of genetic variants annotated. While significant progress has been made in mapping single nucleotide polymorphisms (SNPs) and small (
E-CELL: software environment for whole-cell simulation.
Genome sequencing projects and further systematic functional analyses of complete gene sets are producing an unprecedented mass of molecular information for a wide range of model organisms. This provides us with a detailed account of the cell with which we may begin to build models for simulating intracellular molecular processes to predict the dynamic behavior of living cells. Previous work in biochemical and genetic simulation has isolated well-characterized pathways for detailed...
Potential Breakthroughs in Treating Oral Disease Through Better Understanding of the Oral Microbiome
Most people think of bacteria as the enemy, but scientists at the J. Craig Venter Institute (JCVI) are exploring ways to harness bacteria and phages (the viruses that infect bacteria) as a new way to fight infection. JCVI scientist, Anna Edlund, PhD, is leading one of our efforts to understand the human oral microbiome and learn what role bacteria play in both oral health and disease. Inflammatory gum disease (gingivitis/periodontal disease) and tooth decay are not only the two...
Methanococcus jannaschii genome: revisited.
Analysis of genomic sequences is necessarily an ongoing process. Initial gene assignments tend (wisely) to be on the conservative side (Venter, 1996). The analysis of the genome then grows in an iterative fashion as additional data and more sophisticated algorithms are brought to bear on the data. The present report is an emendation of the original gene list of Methanococcus jannaschii (Bult et al., 1996). By using a somewhat more updated database and more relaxed (and operator-intensive)...
About Harinder Singh
Harinder Singh, PhD is a Staff Scientist in the Infectious Disease Department at the J. Craig Venter Institute (JCVI). Dr. Singh's area of research is mostly focused on various data analysis, data mining, development of prediction algorithm and databases and bioinformatics pipelines for the scientific community. Dr. Singh has significant experience in analyzing proteomics, metabolomics, expression, microbiome and metagenomics datasets using various bioinformatics pipelines. Dr.
Human Microbiome
Both inside and out, our bodies harbor a huge array of bacteria and other microorganisms collectively known as the human microbiome. Although bacteria are often thought to be dangerous, many of those that comprise the microbiome are essential for life. Our researchers are focused on understanding the delicate bacterial balance in the human body and how slight changes in that balance can either improve health or lead to diseases. JCVI Human Microbiome Research Impact Since the...
Every Day is World Food Day at JCVI
World Food Day is a global initiative of the Food and Agriculture Organization (FAO) of the United Nations to ensure that people have access to enough high-quality food to lead active and healthy lives. After a period of decline, world hunger is on the rise again. Today, over 820 million people are suffering chronic undernourishment, according to the latest FAO 2018 State of Food Security and Nutrition in the World report. At JCVI we have several programs aimed at tackling world hunger....
The minimal gene complement of Mycoplasma genitalium.
The complete nucleotide sequence (580,070 base pairs) of the Mycoplasma genitalium genome, the smallest known genome of any free-living organism, has been determined by whole-genome random sequencing and assembly. A total of only 470 predicted coding regions were identified that include genes required for DNA replication, transcription and translation, DNA repair, cellular transport, and energy metabolism. Comparison of this genome to that of Haemophilus influenzae suggests that differences...
About Julie Adelson
Julie Gross Adelson has devoted her career to the practice of health sciences and health care law as an in-house attorney. She is the Vice President and General Counsel for the J. Craig Venter Institute, a world leader in genomic research with more than 200 scientists and staff, and locations in Rockville, Maryland and La Jolla, California. Prior to joining the Institute in 2006, Ms.