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The first genome from the third domain of life.
Hamilton O. Smith Fund
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About Jeffrey M. Hoffman
Jeff Hoffman did his undergraduate and graduate work at Louisiana State University in microbiology. He started work in April 2002 and was the first person hired at the Venter Institute. Since 2002 Jeff has been the Expedition Scientist onboard Sorcerer II. His time on Sorcerer II includes the pilot study in the Sargasso Sea, the circumnavigation around the world from 2004-2006 and the Baltic/Mediterranean/ Black Sea of 2009-2010.
Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease.
The presenilin 1 gene has recently been identified as the locus on chromosome 14 which is responsible for a large proportion of early onset, autosomal dominantly inherited Alzheimer's disease (AD). We have elucidated the intron/exon structure of the gene and designed intronic primers to enable direct sequencing of the entire coding region (10 exons) of the presenilin gene in a large number of families. This strategy has enabled us to find a further two novel mutations in the gene. We...
The NIAID Sponsored Pathogen Functional Genomics Resource Center Announces a Call for White Papers in Functional Genomics and Proteomics
The National Institute of Allergy and Infectious Diseases (NIAID)/NIH/DHHS Pathogen Functional Genomics Resource Center (PFGRC) at the J. Craig Venter Institute (JCVI) is announcing a call for White Papers in the areas of Gene Expression studies, Comparative Genomics, Gene Knock Outs, Proteomics and Bioinformatics as well as associated methodologies and technologies. It is our desire to continue to identify the most relevant resources and collaborative opportunities between the scientific...
Stalking the fourth domain in metagenomic data: searching for, discovering, and interpreting novel, deep branches in marker gene phylogenetic trees.
Most of our knowledge about the ancient evolutionary history of organisms has been derived from data associated with specific known organisms (i.e., organisms that we can study directly such as plants, metazoans, and culturable microbes). Recently, however, a new source of data for such studies has arrived: DNA sequence data generated directly from environmental samples. Such metagenomic data has enormous potential in a variety of areas including, as we argue here, in studies of very early...
cDNA sequencing: a means of understanding cellular physiology.
High-throughput automated sequencing has enabled researchers to examine large numbers of clones from a cDNA library as a measure of the steady-state levels of mRNA species. The past year has witnessed many new applications of this technique to allow the qualitative and quantitative comparison of the changes in transcript levels from multiple genes.