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Researchers look beyond BMI to predict obesity-related disease risk
Scientists at Scripps Research and collaborating corporate and academic partners have found a new way to use distinct molecular “signatures” from people with obesity to predict risk of developing diabetes and cardiovascular disease, an advance that could broaden the way doctors and scientists think about diagnosing and treating disease. The research, led by Amalio Telenti, MD, PhD, professor of genomics at Scripps Research and previously a scientific leader at Human Longevity...
Oral bacteria 'battle royale' helps explain how a pathogen causes hospital infections
Hundreds of different bacterial species are living inside your mouth. Some are highly abundant, while others are scarce. A few of these oral bacteria are known pathogens. Others are benign, or even beneficial. Scientists know the genetic makeup of about 70 percent of oral bacteria. What they don't know is which species would live the longest without nutrients in a "battle royale"--so they decided to find out. The results help explain how certain dangerous bacteria are able to persist in...
Gut Microbiome Sysbiosis in Childhood Acute Lymphoblastic Leukemia (ALL) Patients
An estimated 15,000 children under the age of 19 years are diagnosed with leukemia, lymphoma and other tumors in the USA every year. Acute Lymphoblastic Leukemia (ALL) accounts for 75% of all childhood leukemias. Most of these children and adolescents will undergo chemotherapy as part of their treatment plan and subsequently, their immediate and long-term health can be severely compromised because of repeated administration of cytotoxic drugs. Administration of chemotherapy agents and...
The Baltic Sea Virome: Diversity and Transcriptional Activity of DNA and RNA Viruses.
Metagenomic and metatranscriptomic data were generated from size-fractionated samples from 11 sites within the Baltic Sea and adjacent marine waters of Kattegat and freshwater Lake Torneträsk in order to investigate the diversity, distribution, and transcriptional activity of virioplankton. Such a transect, spanning a salinity gradient from freshwater to the open sea, facilitated a broad genome-enabled investigation of natural as well as impacted aspects of Baltic Sea viral communities....
NHGRI Funds Next Generation Of Large-Scale Sequencing Centers
BETHESDA, Md., Nov. 7, 2003 - The National Human Genome Research Institute (NHGRI) today announced the selection of five centers to carry out a new generation of large-scale sequencing projects designed to maximize the promise of the Human Genome Project and dramatically expand our understanding of human health and disease. "The historic effort to produce a reference sequence of the human genome was successfully completed in April 2003. But our work is far from over. There remains a...
Researchers identify bacteria and viruses ejected from the ocean
Certain types of bacteria and viruses are readily ejected into the atmosphere when waves break while other taxa are less likely to be transported by sea spray into the air, researchers reported May 22. An interdisciplinary team of scientists from Scripps Institution of Oceanography, the University of California San Diego, and the J. Craig Venter Institute (JCVI) reached this conclusion after replicating a phytoplankton bloom in a unique ocean-atmosphere wave facility developed by...
Scientist Spotlight: Meet Vanessa Hayes
Geneticist Vanessa Hayes does not think small nor move slowly—from completing her post doc in six months (the US National average is 3 to 7 years) to completing the first South African Genome Project in 2010 with her goal set on defining the extent of human diversity in all populations, she is on a mission. Just 11 years outside her post doc she has the credentials of someone who has been in science much longer. Her work and talent has taken her to remote regions of Southern Africa,...
Virulence and Drug Resistance of Burkholderia Species Isolated from International Space Station Potable Water Systems
Microbial surveillance of the potable water system (PWS) of the International Space Station (ISS) has been implemented by National Aeronautics and Space Administration (NASA) to ensure crew health within this unique closed environment. The PWS in combination with the potable water dispenser (PWD) is a water recycling system that utilizes physical and chemical techniques to filter, decontaminate, and sterilize water used for drinking and food hydration. These surveillance efforts,...
Governor O’Malley Announces New Life Science Advisory Board Members
ANNAPOLIS, MD – Governor Martin O’Malley today thanked the outgoing members of the Maryland Life Sciences Advisory Board and announced the appointment of seven new members. Created in 2007 by Governor O’Malley, the Board has worked to implement a strategic plan that includes BioMaryland 2020, a 10-year, $1.3 billion strategy for moving Maryland’s life sciences industry forward “I commend the outgoing members of the Life Sciences Advisory board for leading the effort...
Phytoplankton Genetically Sequenced at Sea for the First Time
LOS ANGELES (May 21, 2024) – Viking® (www.viking.com) (NYSE: VIK) today announced its latest scientific advancement on board the company’s expedition fleet with the addition of real-time environmental DNA (eDNA) sequencing of phytoplankton. With scientific support from UC San Diego’s Scripps Institution of Oceanography and J. Craig Venter Institute (JCVI), the PCR lab on board the Viking Octantis® has been converted into an advanced scientific environment where visiting scientists...