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Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing.
Most RNA viruses lack the mechanisms to recognize and correct mutations that arise during genome replication, resulting in quasispecies diversity that is required for pathogenesis and adaptation. However, it is not known how viruses encoding large viral RNA genomes such as the Coronaviridae (26 to 32 kb) balance the requirements for genome stability and quasispecies diversity. Further, the limits of replication infidelity during replication of large RNA genomes and how decreased fidelity...
Synthetic Genomics Vaccines, Inc. Hires Vaccine Executive Sammy J. Farah as President
LA JOLLA, CA — (September 29, 2011) — Synthetic Genomics Vaccines, Inc (SGVI), a privately held company focused on developing next generation vaccines using genomic sequencing and synthetic genomic technologies, announced today that Sammy J. Farah, Ph.D. has been appointed as president. Dr. Farah brings extensive vaccine expertise and over 15 years of scientific, business and executive management experience in the biotechnology industry to SGVI. "We are excited to have...
How to Bake a (Fungal) Turkey
From the kitchen of Stephanie Mounaud, Scientific Project Manager at JCVI Ingredients Media base (see media recipe) Agar Aspergillus terreus (multiple strains) Aspergillus niger Aspergillus fumigatus Aspergillus oryzae Pencillium marneffi Aspergillus flavus Instructions Start with a complex mixture of chemicals to make trace elements media. Sprinkle a little agar in there to get things...
JCVI Gala “2015: A Genome Odyssey” Celebrates Discovery
On October 24th, JCVI welcomed 200 guests to our third annual gala “2015: A Genome Odyssey.” Our annual gala has become a signature La Jolla event, and this year’s guests were not disappointed. Guests experienced an evening odyssey through land, sea and space interacting with JCVI scientists to learn first-hand what explorations are happening today. Proceeds from the gala will support JCVI’s Innovation Fund. As in past galas, our research was the focus. Guests learned how...
Battling Infectious Diseases with 3-D Structures
(CHICAGO) April 25, 2017 — An international team of scientists led by Northwestern University Feinberg School of Medicine has determined the 3-D atomic structure of more than 1,000 proteins that are potential drug and vaccine targets to combat some of the world’s most dangerous emerging and re-emerging infectious diseases. These experimentally determined structures have been deposited into the World-Wide Protein Data Bank, an archive supported by the National Institutes of Health...
Opentrons Announces New Robotics Education Initiative Demonstrating Commitment to Laboratory Automation for Students
BROOKLYN, N.Y. — Opentrons Labworks, Inc., a leader in lab automation and makers of accessible lab robotics, today announced the launch of Opentrons® for Education, an exclusive offering for educators to bring lab automation to the classroom. Opentrons is building a first-of-its-kind ecosystem for teaching with automation, which includes education pricing and support, along with access to a community of educators already teaching with Opentrons. Our goal is to make lab automation a...
President Honors Nation's Top Scientists and Innovators
President Obama today named nine eminent researchers as recipients of the National Medal of Science, and four inventors and one company as recipients of the National Medal of Technology and Innovation, the highest honors bestowed by the United States government on scientists, engineers, and inventors. The recipients will receive their awards on October 7 at a White House ceremony. The National Medal of Science was created by statute in 1959 and is administered for the White House by the...
Researchers look beyond BMI to predict obesity-related disease risk
Scientists at Scripps Research and collaborating corporate and academic partners have found a new way to use distinct molecular “signatures” from people with obesity to predict risk of developing diabetes and cardiovascular disease, an advance that could broaden the way doctors and scientists think about diagnosing and treating disease. The research, led by Amalio Telenti, MD, PhD, professor of genomics at Scripps Research and previously a scientific leader at Human Longevity...
Oral bacteria 'battle royale' helps explain how a pathogen causes hospital infections
Hundreds of different bacterial species are living inside your mouth. Some are highly abundant, while others are scarce. A few of these oral bacteria are known pathogens. Others are benign, or even beneficial. Scientists know the genetic makeup of about 70 percent of oral bacteria. What they don't know is which species would live the longest without nutrients in a "battle royale"--so they decided to find out. The results help explain how certain dangerous bacteria are able to persist in...
Gut Microbiome Sysbiosis in Childhood Acute Lymphoblastic Leukemia (ALL) Patients
An estimated 15,000 children under the age of 19 years are diagnosed with leukemia, lymphoma and other tumors in the USA every year. Acute Lymphoblastic Leukemia (ALL) accounts for 75% of all childhood leukemias. Most of these children and adolescents will undergo chemotherapy as part of their treatment plan and subsequently, their immediate and long-term health can be severely compromised because of repeated administration of cytotoxic drugs. Administration of chemotherapy agents and...