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A Sanger/pyrosequencing hybrid approach for the generation of high-quality draft assemblies of marine microbial genomes.
Since its introduction a decade ago, whole-genome shotgun sequencing (WGS) has been the main approach for producing cost-effective and high-quality genome sequence data. Until now, the Sanger sequencing technology that has served as a platform for WGS has not been truly challenged by emerging technologies. The recent introduction of the pyrosequencing-based 454 sequencing platform (454 Life Sciences, Branford, CT) offers a very promising sequencing technology alternative for incorporation...
The last leg of the Volvo Ocean Race, the Swedish Archipelago and the Gulf of Bothnia Sampling Transect
The morning of June 25th we left Stockholm and followed the Volvo race boats into the Baltic to watch the start of the last leg of the race to St. Petersburg. Once again there were hundreds of boats on the water to watch the start of the race. As the race began we saw someone waving to Dr. Venter and Dr. Norrby from another boat. It turned out to be King Carl XVI Gustaf! (Note: our friends on PUMA achieved second place in the final standing of the race. Congratulations!) After we watched...
Development of a high throughput sequencing and analysis pipeline for West Nile virus
Emmi Mueller1, Rebecca A. Halpin1, Nadia Fedorova1, Timothy B. Stockwell2, Danny Katzel2, Laura Kramer3, Suman R. Das1 1Virology Group and 2Informatics Department, J. Craig Venter Institute, Rockville, MD; and 3 Wadsworth Center, New York State Department of Health, Slingerlands, NY West Nile virus (WNV) is a member of the Flaviviridae family of enveloped, single-stranded RNA viruses with a linear, non-segmented, positive-sense ~11,000bp genome. WNV is an enzootic...
16TH International Genome Sequencing and Analysis Conference Features NIAID Director Anthony Fauci, Biologist E.O. Wilson and other Eminent Scientists
September 20, 2004 Rockville, MD — In the three years since the first analysis and publication of the human genome, the number of sequenced genomes from all branches of life has skyrocketed, the cost to do sequencing has decreased, and the application of genomic knowledge into and its impact on areas such as medicine and health have expanded exponentially. For the past 16 years the International Genome Sequencing and Analysis Conference (GSAC), organized by The Institute for Genomic...
HP and TCAG Collaborate to Advance Medical and Environmental Genomic Discovery in Life Science
BOSTON, Bio-IT World Conference + Expo, March 31, 2004 — HP and The Center for the Advancement of Genomics (TCAG), a policy and research center affiliated with the J. Craig Venter Science Foundation based in Rockville, Md., today announced a formal research and development collaboration to further the goals of advancing medical and environmental genomic discovery in the life sciences. Serving as a real-world test and development environment for tools, systems, and technologies...
Southern African Genome Diversity Study
Overview Scientists at the J. Craig Venter Institute have a long history of leadership in human genomic research. Since the work in the early 1990's by Dr. Venter and colleagues at the National Institutes of Health in describing expressed sequence tags (ESTs) to rapidly discover human genes, to the sequence and analysis of the first draft human genome published in 2001, to the first complete diploid human genome published in 2007, JCVI scientists remain committed to research into the...
Bermuda: Back to Where We Started
Sorcerer II arrived in Bermuda around 7 p.m. on Saturday April 25th after a five day, 1,000 mile sail from Fort Lauderdale, Florida. During the crossing, the crew experienced some challenging weather to say the least. Two samples were collected, and the CTD data confirmed what the J. Craig Venter Institute (JCVI) science team expected: this deep, yet nutrient-poor stretch of open water was very mixed and observed no chlorophyll maximum within 50 meters depth. We are spending...
Q&A with Jessie J. Knight, Jr.
The JCVI CEO Council is a small group of distinguished men and women who are thought leaders in business, medicine, law, the arts and humanities, and community affairs. JCVI is fortunate to have individuals willing to serve as knowledgeable and enthusiastic ambassadors for our scientists and their research, and we are excited to introduce you to our inaugural member, Jessie J. Knight, Jr., Executive Vice President for External Relations at Sempra Energy. Knight is a board member of the...
More than Six Million New Genes, Thousands of New Protein Families, and Incredible Degree of Microbial Diversity Discovered from First Phase of Sorcerer II Global Ocean Sampling Expedition
ROCKVILLE, MD — March 13, 2007 — Researchers from the J. Craig Venter Institute (JCVI) today announced the publication of several studies from the Sorcerer II Global Ocean Sampling Expedition (GOS) in PLoS Biology (www.plosbiology.org) detailing the discovery of millions of new genes, thousands of new protein families and specifically the characterization of thousands of new protein kinases from ocean microbes using whole environment shotgun sequencing and new computational...