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Potential of Aspergillus flavus genomics for applications in biotechnology.
Aspergillus flavus is a common saprophyte and opportunistic pathogen that produces numerous secondary metabolites. The primary objectives of the A. flavus genomics program are to reduce and eliminate aflatoxin contamination in food and feed and to discover genetic factors that contribute to plant and animal pathogenicity. A. flavus expressed sequence tags (ESTs) and whole-genome sequencing have been completed. Annotation of the A. flavus genome has revealed numerous genes and gene clusters...
GCID Outreach: Training the Next Generation of Genomic Scientists
The J. Craig Venter Institute (JCVI) Genomic Center for Infectious Diseases (GCID) was established by the National Institute of Allergy and Infectious Disease (NIAID) to explore disease biology through the application of nucleic acid sequencing and bioinformatics analysis tools. Throughout the history of the program, which is in its third iteration, GCID has been focused on expanding access to these technological platforms through education and outreach. To that end, we have devoted...
TIGR and National Institute of Allergy and Infectious Diseases have launched a new web site on the Aspergillus fumigatus genome project.
TIGR and National Institute of Allergy and Infectious Diseases have launched a new web site on the Aspergillus fumigatus genome project.
Breaking the Mold: Research Teams Sequence Three Fungus Genomes
December 21, 2005 From garden compost to forest greenery, the mold Aspergillus fumigatus lurks across much of the world. And so does its impact. The most common mold causing infection, A. fumigatus triggers allergic reactions, asthma attacks--and even deadly infections among people with weakened immune systems. Now, in the December 22 issue of the journal Nature, scientists at The Institute for Genomic Research (TIGR) and their collaborators report the mold's sequenced genome. The...
Transcriptional profiling identifies a role for BrlA in the response to nitrogen depletion and for StuA in the regulation of secondary metabolite clusters in Aspergillus fumigatus.
Conidiation (asexual sporulation) is a key developmental process in filamentous fungi. We examined the gene regulatory roles of the Aspergillus fumigatus developmental transcription factors StuAp and BrlAp during conidiation. Conidiation was completely abrogated in an A. fumigatus DeltabrlA mutant and was severely impaired in a DeltastuA mutant. We determined the full genome conidiation transcriptomes of wild-type and DeltabrlA and DeltastuA mutant A. fumigatus and found that BrlAp and...
About J. Craig Venter Institute
Pioneering Genomics to Positively Impact Life The J. Craig Venter Institute (JCVI) is a world leader in genomic research with approximately 120 scientists and staff who are bold innovators fearlessly pursuing revolutionary ideas. With a long track-record of creativity and an interdisciplinary approach to genomics, JCVI is committed to accelerating foundational scientific research to drive advances in human health and environmental sustainability. As part of JCVI’s core mission since...
Back to the future for dermatophyte genomics.
Dermatophytes are a uniquely pathogenic group of fungi that cause most common fungal infections globally. The major cause of athlete's foot is Trichophyton rubrum, a pathogen of human skin. A recent paper in this journal reported the sequencing and analysis of five additional genome sequences, including that of Trichophyton rubrum. These five join the existing two additional genome sequences to bring the total to seven dermatophyte genome sequences, a notable milestone in the study of these...
Sub-telomere directed gene expression during initiation of invasive aspergillosis.
Aspergillus fumigatus is a common mould whose spores are a component of the normal airborne flora. Immune dysfunction permits developmental growth of inhaled spores in the human lung causing aspergillosis, a significant threat to human health in the form of allergic, and life-threatening invasive infections. The success of A. fumigatus as a pathogen is unique among close phylogenetic relatives and is poorly characterised at the molecular level. Recent genome sequencing of several...
The inhibitory effect of Bacillus megaterium on aflatoxin and cyclopiazonic acid biosynthetic pathway gene expression in Aspergillus flavus.
Aspergillus flavus is one of the major moulds that colonize peanut in the field and during storage. The impact to human and animal health, and to the economy in agriculture and commerce, is significant since this mold produces the most potent known natural toxins, aflatoxins, which are carcinogenic, mutagenic, immunosuppressive, and teratogenic. A strain of marine Bacillus megaterium isolated from the Yellow Sea of East China was evaluated for its effect in inhibiting aflatoxin formation in...
The aflatoxin pathway regulator AflR induces gene transcription inside and outside of the aflatoxin biosynthetic cluster.
Aflatoxin contamination of food and feed is a major concern due to the carcinogenic properties of this mycotoxin. Previous studies using classical approaches have identified a cluster of genes responsible for aflatoxin production under the control of the pathway-specific transcriptional regulator aflR, but it is unknown whether aflR controls expression of other genes within the genome. Transcription profiling comparing wild type and DeltaaflR strains of Aspergillus parasiticus grown under...
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