Publications

PloS one. 2013-06-19; 8.6: e66462.

Proteomic View of Interactions of Shiga Toxin-Producing Escherichia coli with the Intestinal Environment in Gnotobiotic Piglets

Pieper R, Zhang Q, Clark DJ, Parmar PP, Alami H, Suh MJ, Kuntumalla S, Braisted JC, Huang ST, Tzipori S

PMID: 23840478

Abstract

Shiga toxin (Stx)-producing Escherichia coli cause severe intestinal infections involving colonization of epithelial Peyer's patches and formation of attachment/effacement (A/E) lesions. These lesions trigger leukocyte infiltration followed by inflammation and intestinal hemorrhage. Systems biology, which explores the crosstalk of Stx-producing Escherichia coli with the in vivo host environment, may elucidate novel molecular pathogenesis aspects.

Metrics