Publications

The Journal of infectious diseases. 2020-06-03;

Necroptosis inhibition prevents long-term cardiac damage during pneumococcal pneumonia and invasive disease

Beno SM, Riegler AN, Gilley RP, Brissac T, Wang Y, Kruckow KL, Jadapalli JK, Wright GM, Shenoy AT, Stoner SN, Restrepo MI, Deshane JS, Halade GV, Gonzalez-Juarbe N, Orihuela CJ

PMID: 32492702

Abstract

Streptococcus pneumoniae (Spn) infection can result in bacteremia with devastating consequences including heart damage. Necroptosis is a pro-inflammatory form of cell death instigated by pore-forming toxins such as Spn pneumolysin. Necroptosis-inhibiting drugs may lessen organ damage during invasive pneumococcal disease (IPD).

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