Publications

Antimicrobial agents and chemotherapy. 2017-07-01; 61.7:

NDM-5 and OXA-181 Beta-Lactamases, a Significant Threat Continues To Spread in the Americas

Rojas LJ, Hujer AM, Rudin SD, Wright MS, Domitrovic TN, Marshall SH, Hujer KM, Richter SS, Cober E, Perez F, Adams MD, van Duin D, Bonomo RA

PMID: 28461314

Abstract

Among Gram-negative bacteria, carbapenem-resistant infections pose a serious and life-threatening challenge. Here, the CRACKLE network reports a sentinel detection and characterization of a carbapenem-resistant ST147 isolate harboring and from a young man who underwent abdominal surgery in India. was located on an IncFII plasmid of ≈90 kb, whereas was chromosomally encoded. Resistome and genome analysis demonstrated multiple copies of the transposable element IS and a "hot-spot region" in the IncFII plasmid.

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