Publications

Biology direct. 2006-10-26; 1.34.

Long intervals of stasis punctuated by bursts of positive selection in the seasonal evolution of influenza A virus

Wolf YI, Viboud C, Holmes EC, Koonin EV, Lipman DJ

PMID: 17067369

Abstract

The interpandemic evolution of the influenza A virus hemagglutinin (HA) protein is commonly considered a paragon of rapid evolutionary change under positive selection in which amino acid replacements are fixed by virtue of their effect on antigenicity, enabling the virus to evade immune surveillance.

This publication is listed for reference purposes only. It may be included to present a more complete view of a JCVI employee's body of work, or as a reference to a JCVI sponsored project.

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