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Mutant Nomenclature Rules
Summary of Mutant Nomeclature Rules
Frugoli, J.. 2007; Summary of Mutant Nomenclature Rules. Medicago truncatula Mutant Nomenclature. Retrieved December 22, 2011.
A copy of the article describing the nomenclature rules can be downloaded by clicking here
- Mutant gene symbols should consist of three lower case letters written in italics or underlined (e.g. skl), although symbols longer than 3 letters may be considered if they improve clarity.
- Wild type alleles should consist of the gene symbol in capital letters written in italics or underlined (e.g. SKL).
- Similarly, the full descriptive names of the alleles should be underlined or italicized, and written in lower case for mutants and capitals for wildtype (e.g. sickle or SICKLE).
- Different genes with the same phenotype, which bear the same three letter symbol, will be distinguished by a number following the three letters (e.g. dmi1 vs. dmi2). Different alleles of the same gene will be distinguished by numbers following the symbol, locus number and a hyphen (e.g. dmi1-1 vs. dmi1-2 ).
- Assigning gene symbols to genes identified by mutation:
- Investigators should make an effort to ascertain, through mapping or allelism tests, that the genes described represent loci that are distinct from previously named loci.
- Investigators must avoid redundant use of any three-letter symbol already used for M. truncatula genes of distinctly different phenotype (consult the M. truncatula mutant list).
- If new mutants are sufficiently similar to previously described M. truncatula mutants to imply function in a common pathway or process, it may be appropriate to retain a standard three letter symbol for the phenotype and simply change the locus number.
- Avoid three letter symbols already in use for a family of sequenced genes.
- Avoid symbols used for genes in Arabidopsis, unless the underlying gene is shown to be orthologous (consult the list of Arabidopsis mutant gene names). In the case of orthologous genes, the designation 'Mt' must precede the gene symbol (e.g. MtEin1) so that it is not confused with the gene from the original plant.
- Avoid symbols used to designate symbiotic genes or phenotypes of rhizobia (e.g. fix, nod, exo, and nif)