HMM Summary Page: TIGR04460
| Accession | TIGR04460 |
| Name | endura_MppR |
| Function | enduracididine biosynthesis enzyme MppR |
| Gene Symbol | mppR |
| Trusted Cutoff | 380.00 |
| Domain Trusted Cutoff | 380.00 |
| Noise Cutoff | 240.00 |
| Domain Noise Cutoff | 240.00 |
| Isology Type | equivalog |
| HMM Length | 257 |
| Author | Haft DH |
| Entry Date | Jul 16 2013 4:28PM |
| Last Modified | Jul 16 2013 4:28PM |
| Comment | Members of this family are MppR, one of three enzymes involved in synthesizing enduracididine, a non-proteinogenic amino acid used in non-ribosomal peptide synthases to make natural products such as enduracidin from Streptomyces fungicidicus ATCC 21013. MppR is belongs to the acetoacetate decarboxylase-like superfamily. MppR catalyzes an aldol condensation and a dehydration, not a decarboxylation. |
| References | RN [1] RM PMID:23758195 RT Structural and Functional Characterization of MppR, an Enduracididine Biosynthetic Enzyme from Streptomyces hygroscopicus: Functional Diversity in the Acetoacetate Decarboxylase-like Superfamily. RA Burroughs AM, Hoppe RW, Goebel NC, Sayyed BH, Voegtline TJ, Schwabacher AW, Zabriskie TM, Silvaggi NR RL Biochemistry. 2013 Jul 2;52(26):4492-506. doi: 10.1021/bi400397k. |
| Genome Property | GenProp1084: enduracididine biosynthesis (HMM) |