HMM Summary Page: TIGR04449
| Accession | TIGR04449 |
| Name | halocin_C8_dom |
| Function | halocin C8-like bacteriocin domain |
| Trusted Cutoff | 24.00 |
| Domain Trusted Cutoff | 24.00 |
| Noise Cutoff | 22.50 |
| Domain Noise Cutoff | 20.00 |
| Isology Type | subfamily_domain |
| HMM Length | 69 |
| Author | Haft DH |
| Entry Date | Jun 13 2013 9:48AM |
| Last Modified | Jun 13 2013 9:48AM |
| Comment | This HMM describes the 76-amino C-terminal domain of the halocin C8 precursor that actually becomes the mature bacteriocin halocin C8 after export and cleavage, as well as homologous C-terminal regions from many other archaea. Surprisingly, this Cys-rich region occurs also in many strains of Staphylococcus epidermidis. Gene regions do not provide evidence for post-translational modification other than cleavage. Halocin C8 is active against a broad range of archaea; the region N-terminal to the bacteriocin domain modeled here serves as the immunity protein for the cell secreting the bacteriocin. |
| References | RN [1] RM PMID:18658263 RT The helix-loop-helix motif at the N terminus of HalI is essential for its immunity function against halocin C8. RA Mei S, Sun C, Liu X, Lu Q, Cai L, Li Y, Xiang H RL J Bacteriol. 2008 Oct;190(19):6501-8. |