Accession | TIGR04403 |
Name | rSAM_skfB |
Function | sporulation killing factor system radical SAM maturase |
Gene Symbol | skfB |
Trusted Cutoff | 300.00 |
Domain Trusted Cutoff | 300.00 |
Noise Cutoff | 200.00 |
Domain Noise Cutoff | 200.00 |
Isology Type | equivalog |
HMM Length | 402 |
Author | Haft DH |
Entry Date | Jan 26 2013 5:26PM |
Last Modified | Jan 26 2013 5:26PM |
Comment | Members of this family are a radical SAM enzyme of post-translational modification of ribosomally translated peptides. In Bacillus subtilis, the enzyme SkfB creates a sactipeptide (sulfur-to-alpha-carbon) crosslink of Cys-4 to Met-12 of the mature form of sporulation killing factor (SkfA). In Paenibacillus larvae subsp. larvae B-3650, the Met is replaced by Leu, so the modification must be different. SkfB has 2 4Fe-4S clusters, one in its radical SAM domain (PF04055) and one in a region that somewhat resembles the SPASM domain (TIGR04085). |
References | RN [1]
RM PMID:23282011
RT Two [4Fe-4S] Clusters Containing Radical SAM Enzyme SkfB Catalyze Thioether Bond Formation during the Maturation of the Sporulation Killing Factor.
RA Fluhe L, Burghaus O, Wieckowski BM, Giessen TW, Linne U, Marahiel MA
RL J Am Chem Soc. 2013 Jan 23;135(3):959-62. doi: 10.1021/ja310542g. |
Genome Property | GenProp1078: sporulation killing factor system (HMM) |