HMM Summary Page: TIGR04320
| Accession | TIGR04320 |
| Name | Surf_Exclu_PgrA |
| Function | SEC10/PgrA surface exclusion domain |
| Trusted Cutoff | 70.00 |
| Domain Trusted Cutoff | 70.00 |
| Noise Cutoff | 65.00 |
| Domain Noise Cutoff | 65.00 |
| Isology Type | domain |
| HMM Length | 360 |
| Author | Haft DH |
| Entry Date | Apr 30 2012 5:17PM |
| Last Modified | Aug 12 2012 6:56PM |
| Comment | This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion. |
| References | RN [1] RM PMID:3936037 RT Induction of surface exclusion (entry exclusion) by Streptococcus faecalis sex pheromones: use of monoclonal antibodies to identify an inducible surface antigen involved in the exclusion process. RA Dunny GM, Zimmerman DL, Tortorello ML RL Proc Natl Acad Sci U S A. 1985 Dec;82(24):8582-6. RN [2] RM PMID:1938961 RT Molecular and genetic analysis of a region of plasmid pCF10 containing positive control genes and structural genes encoding surface proteins involved in pheromone-inducible conjugation in Enterococcus faecalis. RA Kao SM, Olmsted SB, Viksnins AS, Gallo JC, Dunny GM RL J Bacteriol. 1991 Dec;173(23):7650-64. RN [3] RM PMID:1603060 RT Sex pheromone plasmid pAD1-encoded surface exclusion protein of Enterococcus faecalis. RA Weidlich G, Wirth R, Galli D RL Mol Gen Genet. 1992 May;233(1-2):161-8. |