Accession | TIGR04240 |
Name | flavi_E_stem |
Function | flavivirus envelope glycoprotein E, stem/anchor domain |
Trusted Cutoff | 26.00 |
Domain Trusted Cutoff | 25.20 |
Noise Cutoff | 25.00 |
Domain Noise Cutoff | 24.80 |
Isology Type | equivalog_domain |
HMM Length | 97 |
Author | Haft DH |
Entry Date | Nov 22 2011 5:07PM |
Last Modified | Nov 22 2011 5:59PM |
Comment | This model describes the C-terminal domain, containing a stem region followed by two transmembrane anchor domains, of the envelope protein E. This protein is cleaved from the large flavivirus polyprotein, which yields three structural and seven nonstructural proteins. |
References | RN [1]
RM PMID:21325407
RT The unique transmembrane hairpin of flavivirus fusion protein E is essential for membrane fusion.
RA Fritz R, Blazevic J, Taucher C, Pangerl K, Heinz FX, Stiasny K
RL J Virol. 2011 May;85(9):4377-85. Epub 2011 Feb 16. |