| Accession | TIGR03973 |
| Name | six_Cys_in_45 |
| Function | six-cysteine peptide SCIFF |
| Gene Symbol | scfA |
| Trusted Cutoff | 50.00 |
| Domain Trusted Cutoff | 50.00 |
| Noise Cutoff | 35.00 |
| Domain Noise Cutoff | 35.00 |
| Isology Type | hypoth_equivalog |
| HMM Length | 43 |
| Author | Haft DH |
| Entry Date | Mar 25 2010 12:30PM |
| Last Modified | Jul 5 2011 12:33PM |
| Comment | Members of this protein family are essentially universal in the class Clostidia and therefore highly abundant in the human gut microbiome. This short peptide is designated SCIFF, for Six Cysteines in Forty-Five residues. It is a presumed ribosomal natural product precursor, always found associated with a yet-uncharacterized radical SAM protein, family TIGR03974, that resembles other peptide modification radical SAM enzymes and is designated SCIFF radical SAM maturase. |
| References | RN [1]
RM PMID:21478363
RT Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational mo
dification.
RA Haft DH, Basu MK
RL J Bacteriol. 2011 Jun;193(11):2745-55. |
| Genome Property | GenProp0919: SCIFF/radical SAM Clostridial gene pair (HMM) |
