| Accession | TIGR03897 |
| Name | lanti_2_LanM |
| Function | type 2 lantibiotic biosynthesis protein LanM |
| Gene Symbol | lanM |
| Trusted Cutoff | 304.00 |
| Domain Trusted Cutoff | 304.00 |
| Noise Cutoff | 287.60 |
| Domain Noise Cutoff | 287.60 |
| Isology Type | subfamily |
| HMM Length | 932 |
| Author | Haft DH |
| Entry Date | Dec 10 2009 9:27AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this family are known generally as LanM, a multifunctional enzyme of lantibiotic biosynthesis. This catalysis by LanM distinguishes the type 2 lantibiotics, such as mersacidin, cinnamycin, and lichenicidin, from LanBC-produced type 1 lantibiotics such as nisin and subtilin. The N-terminal domain contains regions associated with Ser and Thr dehydration. The C-terminal region contains a PF05147 domain, which catalyzes the formation of the lanthionine bridge. |
| References | RN [1]
RM PMID:19561184
RT Identification of a novel two-peptide lantibiotic, lichenicidin, following rational genome mining for LanM proteins.
RA Begley M, Cotter PD, Hill C, Ross RP
RL Appl Environ Microbiol. 2009 Sep;75(17):5451-60. |
