HMM Summary Page: TIGR03893
| Accession | TIGR03893 |
| Name | lant_SP_1948 |
| Function | type 2 lantibiotic, SP_1948 family |
| Trusted Cutoff | 32.95 |
| Domain Trusted Cutoff | 32.95 |
| Noise Cutoff | 32.65 |
| Domain Noise Cutoff | 32.65 |
| Isology Type | subfamily |
| HMM Length | 61 |
| Author | Haft DH |
| Entry Date | Dec 4 2009 9:39AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM recognizes a number of type 2 lantibiotic-type bacteriocins, related to but distinct from the family that includes lichenicidin and mersacidin. Sequence similarity among members consists largely of a 20-residue block of conserved sequence that covers most of the leader peptide region, absent from the mature lantibiotic. This is followed by a region with characteristic composition for lantibiotic precursor regions, rich in Ser and Thr and including a near-invariant Cys near or at the C-terminus, involved in cyclization. Members of this family typically are shorter than 70 amino acids. |
| References | RN [1] RM PMID:19477413 RT Dissecting structural and functional diversity of the lantibiotic mersacidin. RA Appleyard AN, Choi S, Read DM, Lightfoot A, Boakes S, Hoffmann A, Chopra I, Bierbaum G, Rudd BA, Dawson MJ, Cortes J RL Chem Biol. 2009 May 29;16(5):490-8. |