| Accession | TIGR03691 |
| Name | 20S_bact_alpha |
| Function | proteasome, alpha subunit |
| Gene Symbol | prcA |
| Trusted Cutoff | 139.05 |
| Domain Trusted Cutoff | 139.05 |
| Noise Cutoff | 62.65 |
| Domain Noise Cutoff | 62.65 |
| Isology Type | equivalog |
| EC Number | 3.4.25.1 |
| HMM Length | 229 |
| Mainrole Category | Protein fate |
| Subrole Category | Degradation of proteins, peptides, and glycopeptides |
| Gene Ontology Term | GO:0004298: threonine-type endopeptidase activity molecular_function |
| | GO:0005839: proteasome core complex cellular_component |
| | GO:0010498: proteasomal protein catabolic process biological_process |
| Author | Haft DH |
| Entry Date | Nov 6 2008 10:20AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this family are the alpha subunit of the 20S proteasome as found in Actinobacteria such as Mycobacterium, Rhodococcus, and Streptomyces. In most Actinobacteria (an exception is Propionibacterium acnes), the proteasome is accompanied by a system of tagging proteins for degradation with Pup. |
| References | RN [1]
RM PMID:9765579
RT The 20S proteasome of Streptomyces coelicolor.
RA Nagy I, Tamura T, Vanderleyden J, Baumeister W, De Mot R
RL J Bacteriol. 1998 Oct;180(20):5448-53.
RN [2]
RM PMID:16468985
RT Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity.
RA Lin G, Hu G, Tsu C, Kunes YZ, Li H, Dick L, Parsons T, Li P, Chen Z, Zwickl P, Weich N, Nathan C
RL Mol Microbiol. 2006 Mar;59(5):1405-16. |
| Genome Property | GenProp0834: proteasome, bacterial (HMM) |
