HMM Summary Page: TIGR03666

AccessionTIGR03666
NameRv2061_F420
FunctionPPOX class probable F420-dependent enzyme, Rv2061 family
Trusted Cutoff84.90
Domain Trusted Cutoff84.90
Noise Cutoff50.75
Domain Noise Cutoff50.75
Isology Typesubfamily
EC Number1.-.-.-
HMM Length132
AuthorHaft DH
Entry DateOct 20 2008 7:54AM
Last ModifiedFeb 14 2011 3:27PM
CommentA Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomycetales, make F420. A variant of the Partial Phylogenetic Profiling algorithm, SIMBAL, shows that this protein likely binds F420 in a cleft similar to that in which the homologous enzyme pyridoxamine phosphate oxidase (PPOX) binds FMN.
ReferencesRN [1] RM PMID:20675471 RT Unexpected abundance of coenzyme F(420)-dependent enzymes in Mycobacterium tuberculosis and other actinobacteria. RA Selengut JD, Haft DH RL J Bacteriol. 2010 Nov;192(21):5788-98.
Genome PropertyGenProp0002: coenzyme F420 utilization (HMM)