| Comment | This region is found at, or about 200 amino acids from, the N-terminus of FimV from Pseudomonas aeruginosa, TspA of Neisseria meningitidis, and related proteins. Disruption of FimV blocks twitching motility from type IV pili; Semmler, et al. suggest a role for this family in peptidoglycan layer remodelling required by type IV fimbrial systems. Most but not all members of this protein family have a C-terminal region recognized by TIGR03504. In between is a highly variable, often repeat-filled region rich in the negatively charged amino acids Asp and Glu. |
| References | RN [1]
RM PMID:10846211
RT Identification of a novel gene, fimV, involved in twitching motility in Pseudomonas aeruginosa.
RA Semmler AB, Whitchurch CB, Leech AJ, Mattick JS
RL Microbiology. 2000 Jun;146 ( Pt 6):1321-32.
RN [2]
RM PMID:10377136
RT Identification and characterization of TspA, a major CD4(+) T-cell- and B-cell-stimulating Neisseria-specific antigen.
RA Kizil G, Todd I, Atta M, Borriello SP, Ait-Tahar K, Ala'Aldeen DA
RL Infect Immun. 1999 Jul;67(7):3533-41. |
