Accession | TIGR03462 |
Name | CarR_dom_SF |
Function | lycopene cyclase domain |
Trusted Cutoff | 39.40 |
Domain Trusted Cutoff | 39.40 |
Noise Cutoff | 29.50 |
Domain Noise Cutoff | 29.50 |
Isology Type | subfamily_domain |
HMM Length | 89 |
Author | Selengut J |
Entry Date | Jul 30 2007 2:02PM |
Last Modified | Dec 21 2011 12:25PM |
Comment | This domain is often repeated twice within the same polypeptide, as is observed in Archaea, Thermus, Sphingobacteria [1] and Fungi. In the fungal sequences, this tandem domain pair is observed as the N-terminal half of a bifunctional protein [2], where it has been characterized as a lycopene beta-cyclase and the C-terminal half is a phytoene synthetase. In Myxococcus and Actinobacterial genomes this domain appears as a single polypeptide, tandemly repeated and usually in a genomic context consistent with a role in carotenoid biosynthesis. It is unclear whether any of the sequences in this family truly encode lycopene epsilon cyclases. However a number are annotated as such.
The domain is generally hydrophobic with a number of predicted membrane spanning segments and contains a distinctive motif (hPhEEhhhhhh). In certain sequences one of either the proline or glutamates may vary, but always one of the tandem pair appear to match this canonical sequence exactly. |
References | RN [1]
RM PMID:16625353
RT A carotenoid synthesis gene cluster from Algoriphagus sp. KK10202C with a novel fusion-type lycopene beta-cyclase gene.
RA Tao L, Yao H, Kasai H, Misawa N, Cheng Q
RL Mol Genet Genomics. 2006 Jul;276(1):79-86. Epub 2006 Apr 20.
RN [2]
RM PMID:10951210
RT A bifunctional enzyme with lycopene cyclase and phytoene synthase activities is encoded by the carRP gene of Mucor circinelloides.
RA Velayos A, Eslava AP, Iturriaga EA
RL Eur J Biochem. 2000 Sep;267(17):5509-19. |
Genome Property | GenProp0758: lycopene biosynthesis from IPP (HMM) |