| Accession | TIGR03344 |
| Name | VI_effect_Hcp1 |
| Function | type VI secretion system effector, Hcp1 family |
| Trusted Cutoff | 58.90 |
| Domain Trusted Cutoff | 58.90 |
| Noise Cutoff | 32.40 |
| Domain Noise Cutoff | 32.40 |
| Isology Type | subfamily |
| HMM Length | 167 |
| Mainrole Category | Cellular processes |
| Subrole Category | Pathogenesis |
| Gene Ontology Term | GO:0003674: molecular_function molecular_function |
| | GO:0009405: pathogenesis biological_process |
| | GO:0052048: interaction with host via secreted substance involved in symbiotic interaction biological_process |
| Author | Haft DH |
| Entry Date | Mar 14 2007 10:09AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This family includes Hcp1 (hemolysin coregulated protein 1), an exported, homohexameric ring-forming virulence protein from Pseudomonas aeruginosa. Hcp1 lacks a conventional signal sequence and is instead exported by means of the type VI secretion system, encoded by a pathogenicity cluster of a class previously designated IAHP (IcmF-associated homologous protein). Homologs of Hcp1, in this protein family, are found in various bacteria of which most but not all are known pathogens. Pathogens may have many multiple members of this family, with three to ten in Erwinia carotovora, Yersinia pestis, uropathogenic Escherichia coli, and the insect pathogen Photorhabdus luminescens. |
| References | RN [1]
RM PMID: 16763151
RT A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus.
RA Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordonez CL, Lory S, Walz T, Joachimiak A, Mekalanos JJ
RL Science. 2006 Jun 9;312(5779):1526-30. |
| Genome Property | GenProp0735: type VI secretion (HMM) |
