| Accession | TIGR03335 |
| Name | F390_ftsA |
| Function | coenzyme F390 synthetase |
| Gene Symbol | ftsA |
| Trusted Cutoff | 458.70 |
| Domain Trusted Cutoff | 458.70 |
| Noise Cutoff | 458.45 |
| Domain Noise Cutoff | 458.45 |
| Isology Type | equivalog |
| EC Number | 2.7.7.- |
| HMM Length | 445 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Other |
| Author | Haft DH |
| Entry Date | Mar 7 2007 1:21PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This enzyme, characterized in Methanobacterium thermoautotrophicum and found in several other methanogens, modifies coenzyme F420 by ligation of AMP (or GMP) from ATP (or GTP). On F420, it activates an aromatic hydroxyl group, which is unusual chemistry for an adenylyltransferase. This enzyme name has been attached to numbers of uncharacterized genes likely to instead act as phenylacetate CoA ligase, based on proximity to predicted indolepyruvate ferredoxin oxidoreductase (1.2.7.8) genes. The enzyme acts during transient exposure of the organism to oxygen. |
| References | RN [1]
RM PMID: 8550473
RT Coenzyme F390 synthetase from Methanobacterium thermoautotrophicum Marburg belongs to the superfamily of adenylate-forming enzymes.
RA Vermeij P, van der Steen RJ, Keltjens JT, Vogels GD, Leisinger T
RL J Bacteriol. 1996 Jan;178(2):505-10. |
