| Comment | Enzymes in this family catalyze the NAD-dependent alcohol-to-acid oxidation of nucleotide-linked sugars. Examples include UDP-glucose 6-dehydrogenase (1.1.1.22) [1], GDP-mannose 6-dehydrogenase (1.1.1.132) [2], UDP-N-acetylglucosamine 6-dehydrogenase (1.1.1.136) [3], UDP-N-acetyl-D-galactosaminuronic acid dehydrogenase [4] and UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase [5]. These enzymes are most often involved in the biosynthesis of polysaccharides and are often found in operons devoted to that purpose.
All of these enzymes contain three Pfam domains, PF03721, PF00984, and PF03720 for the N-terminal, central, and C-terminal regions respectively. |
| References | RN [1]
RM PMID: 10376820
RT Assay for UDPglucose 6-dehydrogenase in phosphate-starved cells: gene tuaD of Bacillus subtilis 168 encodes the UDPglucose 6-dehydrogenase involved in teichuronic acid synthesis.
RA Pagni M, Lazarevic V, Soldo B, Karamata D
RL Microbiology. 1999 May;145 ( Pt 5):1049-53.
RN [2]
RM PMID: 8606150
RT Characterization of the gene coding for GDP-mannose dehydrogenase (algD) from Azotobacter vinelandii.
RA Campos M, Martinez-Salazar JM, Lloret L, Moreno S, Nunez C, Espin G, Soberon-Chavez G
RL J Bacteriol. 1996 Apr;178(7):1793-9.
RN [3]
RM PMID: 15226302
RT Biochemical characterization of WbpA, a UDP-N-acetyl-D-glucosamine 6-dehydrogenase involved in O-antigen biosynthesis in Pseudomonas aeruginosa PAO1.
RA Miller WL, Wenzel CQ, Daniels C, Larocque S, Brisson JR, Lam JS
RL J Biol Chem. 2004 Sep 3;279(36):37551-8. Epub 2004 Jun 28.
RN [4]
RM PMID: 10931835
RT WbpO, a UDP-N-acetyl-D-galactosamine dehydrogenase from Pseudomonas aeruginosa serotype O6.
RA Zhao X, Creuzenet C, Belanger M, Egbosimba E, Li J, Lam JS
RL J Biol Chem. 2000 Oct 27;275(43):33252-9.
RN [5]
RM PMID: 2166030
RT Biosynthesis of enterobacterial common antigen in Escherichia coli. Biochemical characterization of Tn10 insertion mutants defective in enterobacterial common antigen synthesis.
RA Meier-Dieter U, Starman R, Barr K, Mayer H, Rick PD
RL J Biol Chem. 1990 Aug 15;265(23):13490-7. |
