Accession | TIGR02776 |
Name | NHEJ_ligase_prk |
Function | DNA ligase D |
Gene Symbol | ligD |
Trusted Cutoff | 373.20 |
Domain Trusted Cutoff | 373.20 |
Noise Cutoff | 221.10 |
Domain Noise Cutoff | 221.10 |
Isology Type | equivalog |
HMM Length | 587 |
Mainrole Category | DNA metabolism |
Subrole Category | DNA replication, recombination, and repair |
Gene Ontology Term | GO:0006303: double-strand break repair via nonhomologous end joining biological_process |
Author | Haft DH |
Entry Date | Jan 10 2006 10:00AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | Members of this protein family are DNA ligases involved in the repair of DNA double-stranded breaks by non-homologous end joining (NHEJ). The system of the bacterial Ku protein (TIGR02772) plus this DNA ligase is seen in about 20 % of bacterial genomes to date and at least one archaeon (Archeoglobus fulgidus). This model describes a central and a C-terminal domain. These two domains may be permuted, as in genus Mycobacterium, or divided into tandem ORFs, and therefore not be identified by this HMM. An additional N-terminal 3'-phosphoesterase (PE) domain present in some but not all examples of this ligase is not included in the seed alignment for this model; this HMM models only the central ATP-dependent ligase domain and the C-terminal polymerase domain. Most examples of genes for this ligase are adjacent to the gene for Ku. |
References | RN [1]
RM 16046407
RT Essential constituents of the 3'-phosphoesterase domain of bacterial DNA ligase D, a nonhomologous end-joining enzyme.
RA Zhu H, Wang LK, Shuman S.
RL J Biol Chem. 2005 Oct 7;280(40):33707-15. |