| Accession | TIGR02706 |
| Name | P_butyryltrans |
| Function | phosphate butyryltransferase |
| Gene Symbol | ptb |
| Trusted Cutoff | 410.50 |
| Domain Trusted Cutoff | 410.50 |
| Noise Cutoff | 339.40 |
| Domain Noise Cutoff | 339.40 |
| Isology Type | equivalog |
| EC Number | 2.3.1.19 |
| HMM Length | 294 |
| Mainrole Category | Energy metabolism |
| Subrole Category | Fermentation |
| Gene Ontology Term | GO:0006113: fermentation biological_process |
| | GO:0050182: phosphate butyryltransferase activity molecular_function |
| Author | Haft DH |
| Entry Date | Nov 28 2005 12:52PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this family are phosphate butyryltransferase, also called phosphotransbutyrylase. In general, this enzyme is found in butyrate-producing anaerobic bacteria, encoded next to the gene for butyrate kinase. Together, these two enzymes represent what may be the less common of two pathways for butyrate production from butyryl-CoA. The alternative is transfer of the CoA group to acetate by butyryl-CoA:acetate CoA transferase. Cutoffs for this model are set such that the homolog from Thermotoga maritima, whose activity on butyryl-CoA is only 30 % of its activity with acetyl-CoA, scores in the zone between trusted and noice cutoffs. |
| References | DR PFAM; PF01515; PTA_PTB; Phosphate acetyl/butyryl transferase
RN [1]
RM 15028695
RT Restricted distribution of the butyrate kinase pathway among butyrate-producing bacteria from the human colon.
RA Louis P, Duncan SH, McCrae SI, Millar J, Jackson MS, Flint HJ.
RL J Bacteriol. 2004 Apr;186(7):2099-106.
RN [2]
RM 10074080
RT Purification and characterization of two extremely thermostable enzymes, phosphate acetyltransferase and acetate kinase, from the hyperthermophilic eubacterium Thermotoga maritima.
RA Bock AK, Glasemacher J, Schmidt R, Schonheit P.
RL J Bacteriol. 1999 Mar;181(6):1861-7. |
| Genome Property | GenProp0910: butyryl-CoA to butyrate, phosphotransbutyrylase pathway (HMM) |
