Accession | TIGR02698 |
Name | CopY_TcrY |
Function | copper transport repressor, CopY/TcrY family |
Trusted Cutoff | 121.95 |
Domain Trusted Cutoff | 121.95 |
Noise Cutoff | 112.15 |
Domain Noise Cutoff | 112.15 |
Isology Type | equivalog |
HMM Length | 130 |
Mainrole Category | Transport and binding proteins |
Subrole Category | Cations and iron carrying compounds |
Gene Ontology Term | GO:0006355: regulation of transcription, DNA-dependent biological_process |
| GO:0006825: copper ion transport biological_process |
| GO:0016564: transcription repressor activity molecular_function |
Author | Haft DH |
Entry Date | Nov 21 2005 1:22PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This family includes metal-fist type transcriptional repressors of copper transport systems such as copYZAB of Enterococcus hirae and tcrYAZB (transferble copper resistance) of an Enterocuccus faecium plasmid. High levels of copper can displace zinc and prevent binding by the repressor, activating efflux by copper resistance transporters. The most closely related proteins excluded by this model are antibiotic resistance regulators including the methicillin resistance regulatory protein MecI. |
References | DR PFAM; PF03965; Pencillinase_R; transcriptional regulator, BlaI/MecI/CopY family
RM 16151212
RT The tcrB gene is part of the tcrYAZB operon conferring copper resistance in Enterococcus faecium and Enterococcus faecalis.
RA Hasman H.
RL Microbiology. 2005 Sep;151(Pt 9):3019-25. |
Genome Property | GenProp0477: copper resistance system: CopZA (HMM) |