| Accession | TIGR02650 |
| Name | RNase_Z_T_toga |
| Function | ribonuclease Z, Thermotoga type |
| Gene Symbol | rnz |
| Trusted Cutoff | 507.05 |
| Domain Trusted Cutoff | 507.05 |
| Noise Cutoff | 92.35 |
| Domain Noise Cutoff | 92.35 |
| Isology Type | equivalog |
| EC Number | 3.1.26.11 |
| HMM Length | 277 |
| Mainrole Category | Transcription |
| Subrole Category | RNA processing |
| Author | Haft DH |
| Entry Date | Aug 30 2005 4:13PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein family are ribonuclease Z as found in the genus Thermotoga, where the enzyme cleaves after the CCA, in contrast to the activities characterized for other enzymes also designated ribonuclease Z. In other systems, cleavage occurs 5-prime to the location of the CCA sequence, and CCA is added subsequently. A species may lack ribonuclease Z if all tRNA genes encode the CCA sequence, or if the CCA is exposed by exonuclease activity rather than endonuclease activity. Note that members of this sequence family differ considerably from the majority of RNase Z sequences. |
| References | DR PFAM; PF00753; metallo-beta-lactamase superfamily
RN [1]
RM 15701599
RT Crystal structure of the tRNA 3' processing endoribonuclease tRNase Z from Thermotoga maritima.
RA Ishii R, Minagawa A, Takaku H, Takagi M, Nashimoto M, Yokoyama S.
RL J Biol Chem. 2005 Apr 8;280(14):14138-44. |
