HMM Summary Page: TIGR02486
Accession | TIGR02486 |
Name | RDH |
Function | reductive dehalogenase |
Trusted Cutoff | 160.35 |
Domain Trusted Cutoff | 160.35 |
Noise Cutoff | 132.25 |
Domain Noise Cutoff | 132.25 |
Isology Type | subfamily |
EC Number | 1.97.1.- |
HMM Length | 314 |
Author | Selengut J |
Entry Date | Feb 24 2005 9:28AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This model represents a family of corrin and 8-iron Fe-S cluster-containing reductive dehalogenases [1] found primarily in halorespiring microorganisms such as dehalococcoides ethenogenes which contains as many as 17 enzymes of this type with varying substrate ranges. One example of a characterized species is the tetrachloroethene reductive dehalogenase [2] (1.97.1.8) which also acts on trichloroethene converting it to dichloroethene. |
References | RN [1] RM PMID: 11097881 RT Trichloroethene reductive dehalogenase from Dehalococcoides ethenogenes: sequence of tceA and substrate range characterization. RA Magnuson JK, Romine MF, Burris DR, Kingsley MT. RL Appl Environ Microbiol. 2000 Dec;66(12):5141-7. RN [2] RM PMID: 9224702 RT Redox chemistry of cobalamin and iron-sulfur cofactors in the tetrachloroethene reductase of Dehalobacter restrictus. RA Schumacher W, Holliger C, Zehnder AJ, Hagen WR. RL FEBS Lett. 1997 Jun 16;409(3):421-5. |
Genome Property | GenProp0284: cobalamin-utilizing enzymes (HMM) |