Accession | TIGR02381 |
Name | cspD |
Function | cold shock domain protein CspD |
Gene Symbol | cspD |
Trusted Cutoff | 115.40 |
Domain Trusted Cutoff | 115.40 |
Noise Cutoff | 113.00 |
Domain Noise Cutoff | 113.00 |
Isology Type | equivalog |
HMM Length | 68 |
Mainrole Category | DNA metabolism |
Subrole Category | DNA replication, recombination, and repair |
Gene Ontology Term | GO:0008156: negative regulation of DNA replication biological_process |
| GO:0009409: response to cold biological_process |
Author | Haft DH |
Entry Date | Nov 24 2004 2:23PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This HMM represents what appears to be a phylogenetically distinct clade, containing E. coli CspD (SP|P24245) and related proteobacterial proteins within the larger family of cold shock domain proteins described by Pfam HMM PF00313. The gene symbol cspD may have been used idependently for other subfamilies of cold shock domain proteins, such as for B. subtilis CspD. These proteins typically are shorter than 70 amino acids. In E. coli, CspD is a stress response protein induced in stationary phase. This homodimer binds single-stranded DNA and appears to inhibit DNA replication [1]. |
References | DR PFAM; PF00313; CSD
RN [1]
RM 11260474
RT CspD, a novel DNA replication inhibitor induced during the stationary phase in Escherichia coli.
RA Yamanaka K, Zheng W, Crooke E, Wang YH, Inouye M.
RL Mol Microbiol. 2001 Mar;39(6):1572-84. |