| Accession | TIGR02359 |
| Name | thiW |
| Function | energy coupling factor transporter S component ThiW |
| Gene Symbol | thiW |
| Trusted Cutoff | 84.35 |
| Domain Trusted Cutoff | 84.35 |
| Noise Cutoff | 33.75 |
| Domain Noise Cutoff | 33.75 |
| Isology Type | equivalog |
| HMM Length | 160 |
| Mainrole Category | Transport and binding proteins |
| Subrole Category | Other |
| Gene Ontology Term | GO:0009228: thiamine biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Oct 20 2004 4:52PM |
| Last Modified | Mar 14 2014 11:28AM |
| Comment | Levels of thiamine pyrophosphate (TPP) or thiamine regulate transcription or translation of a number of thiamine biosynthesis, salvage, or transport genes in a wide range of prokaryotes. The mechanism involves direct binding, with no protein involved,to a structural element called THI found in the untranslated upstream region of thiamine metabolism gene operons. This element is called a riboswitch and is seen also for other metabolites such as FMN and glycine. This protein family consists of proteins identified in operons controlled by the THI riboswitch and designated ThiW. The hydrophobic nature of this protein and reconstructed metabolic background suggests that this protein acts in transport of a thiazole precursor of thiamine. |
| References | RM 12376536
RT Comparative genomics of thiamin biosynthesis in procaryotes. New genes and regulatory mechanisms.
RA Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS.
RL J Biol Chem. 2002 Dec 13;277(50):48949-59.
RN [2]
RM PMID:18931129
RT A novel class of modular transporters for vitamins in prokaryotes.
RA Rodionov DA, Hebbeln P, Eudes A, ter Beek J, Rodionova IA, Erkens GB, Slotboom DJ, Gelfand MS, Osterman AL, Hanson AD, Eitinger T
RL J Bacteriol. 2009 Jan;191(1):42-51. doi: 10.1128/JB.01208-08. |
| Genome Property | GenProp1094: energy-coupling factor transporters (HMM) |
