| Accession | TIGR02170 |
| Name | thyX |
| Function | thymidylate synthase, flavin-dependent |
| Gene Symbol | thyX |
| Trusted Cutoff | 87.90 |
| Domain Trusted Cutoff | 87.90 |
| Noise Cutoff | 67.10 |
| Domain Noise Cutoff | 67.10 |
| Isology Type | equivalog |
| EC Number | 2.1.1.148 |
| HMM Length | 211 |
| Mainrole Category | Purines, pyrimidines, nucleosides, and nucleotides |
| Subrole Category | 2'-Deoxyribonucleotide metabolism |
| Gene Ontology Term | GO:0009265: 2'-deoxyribonucleotide biosynthetic process biological_process |
| | GO:0050797: thymidylate synthase (FAD) activity molecular_function |
| Author | Haft DH |
| Entry Date | Apr 23 2004 2:52PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Two forms of microbial thymidylate synthase are known: ThyA (2.1.1.45) and ThyX (2.1.1.148). This model describes ThyX, a homotetrameric flavoprotein. Both enzymes convert dUMP to dTMP. Under oxygen-limiting conditions, thyX can complement a thyA mutation. |
| References | DR PFAM; PF02511; Thy1
RN [1]
RM 15046578
RT Two distinct pathways for thymidylate (dTMP) synthesis in (hyper)thermophilic Bacteria and Archaea.
RA Leduc D, Graziani S, Meslet-Cladiere L, Sodolescu A, Liebl U, Myllykallio H.
RL Biochem Soc Trans. 2004 Apr;32(Pt 2):231-5.
DR HAMAP; MF_01408; 48 of 48 |
