| Accession | TIGR02168 |
| Name | SMC_prok_B |
| Function | chromosome segregation protein SMC |
| Gene Symbol | smc |
| Trusted Cutoff | 567.35 |
| Domain Trusted Cutoff | 567.35 |
| Noise Cutoff | 557.95 |
| Domain Noise Cutoff | 557.95 |
| Isology Type | equivalog |
| HMM Length | 1181 |
| Mainrole Category | Cellular processes |
| Subrole Category | Cell division |
| Gene Ontology Term | GO:0005524: ATP binding molecular_function |
| | GO:0007059: chromosome segregation biological_process |
| | GO:0030261: chromosome condensation biological_process |
| Author | Haft DH |
| Entry Date | Apr 22 2004 10:07AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. |
| References | RN [1]
RM 12730166
RT Cell-cycle-regulated expression and subcellular localization of the Caulobacter crescentus SMC chromosome structural protein.
RA Jensen RB, Shapiro L.
RL J Bacteriol. 2003 May;185(10):3068-75.
RN [2]
RM 12100548
RT Discovery of two novel families of proteins that are proposed to interact with prokaryotic SMC proteins, and characterization of the Bacillus subtilis family members ScpA and ScpB.
RL Mol Microbiol. 2002 Jul;45(1):59-71.
RA Soppa J, Kobayashi K, Noirot-Gros MF, Oesterhelt D, Ehrlich SD, Dervyn E, Ogasawara N, Moriya S.
RN [3]
RM 12411491
RT Hinge-mediated dimerization of SMC protein is essential for its dynamic interaction with DNA.
RA Hirano M, Hirano T.
RL EMBO J. 2002 Nov 1;21(21):5733-44. |
| Genome Property | GenProp0201: SMC-ScpA-ScpB complex (HMM) |
