Accession | TIGR01925 |
Name | spIIAB |
Function | anti-sigma F factor |
Gene Symbol | spoIIAB |
Trusted Cutoff | 91.75 |
Domain Trusted Cutoff | 91.75 |
Noise Cutoff | 78.90 |
Domain Noise Cutoff | 78.90 |
Isology Type | equivalog |
EC Number | 2.7.11.1 |
HMM Length | 137 |
Mainrole Category | Regulatory functions |
Subrole Category | Protein interactions |
Gene Ontology Term | GO:0004672: protein kinase activity molecular_function |
| GO:0030436: asexual sporulation biological_process |
Author | Nelson WE |
Entry Date | Jul 15 2003 9:40AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This model describes the SpoIIAB anti-sigma F factor. Sigma F regulates spore development in B subtilis. SpoIIAB binds to sigma F, preventing formation of the transcription complex at the promoter.[1] SpoIIAA (anti-anti-sigma F factor) binds to SpoIIAB to inhibit association with sigma F, however SpoIIAB can phosphorylate SpoIIAA, causing disassociation of the SpoIIAA/B complex.[2] The SpoIIE phosphatase dephosphorylates SpoIIAA. |
References | RN [1]
RM 8460142
RT SpoIIAB is an anti-sigma factor that binds to and inhibits transcription by regulatory protein sigma F from Bacillus subtilis.
RA Duncan L, Losick R.
RL Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2325-9.
RN [2]
RM 8358793
RT Sigma F, the first compartment-specific transcription factor of B. subtilis, is regulated by an anti-sigma factor that is also a protein kinase.
RA Min KT, Hilditch CM, Diederich B, Errington J, Yudkin MD.
RL Cell. 1993 Aug 27;74(4):735-42.
DR HAMAP; MF_00637; 29 of 29 |
Genome Property | GenProp0610: endospore formation marker gene set (HMM) |