HMM Summary Page: TIGR01924
| Accession | TIGR01924 |
| Name | rsbW_low_gc |
| Function | anti-sigma B factor |
| Gene Symbol | rsbW |
| Trusted Cutoff | 155.05 |
| Domain Trusted Cutoff | 155.05 |
| Noise Cutoff | 100.10 |
| Domain Noise Cutoff | 100.10 |
| Isology Type | equivalog |
| EC Number | 2.7.11.1 |
| HMM Length | 159 |
| Author | Nelson WE, Selengut J |
| Entry Date | Jul 11 2003 5:31PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model describes the anti-sigma B factor also known as serine-protein kinase RsbW. Sigma B controls the general stress regulon in B subtilis and is activated by cell stresses such as stationary phase and heat shock. RsbW binds to sigma B and prevents formation of the transcription complex at the promoter.[1] RsbV (anti-anti-sigma factor) binds to RsbW to inhibit association with sigma B, however RsbW can phosphorylate RsbV, causing disassociation of the RsbV/RsbW complex.[2] Low ATP level or environmental stress causes the dephosphorylation of RsbV.[3] |
| References | RN [1] RM PMID: 8460143 RT Bacillus subtilis sigma B is regulated by a binding protein (RsbW) that blocks its association with core RNA polymerase. RA Benson AK, Haldenwang WG. RL Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2330-4. RN [2] RM PMID: 8144446 RT Interactions between a Bacillus subtilis anti-sigma factor (RsbW) and its antagonist (RsbV). RA Dufour A, Haldenwang WG. RL J Bacteriol. 1994 Apr;176(7):1813-20. RN [3] RM PMID: 8808936 RT Reactivation of the Bacillus subtilis anti-sigma B antagonist, RsbV, by stress- or starvation-induced phosphatase activities. RA Voelker U, Voelker A, Haldenwang WG. RL J Bacteriol. 1996 Sep;178(18):5456-63. DR HAMAP; MF_00638; 35 of 35 |