Accession | TIGR01628 |
Name | PABP-1234 |
Function | polyadenylate binding protein, human types 1, 2, 3, 4 family |
Trusted Cutoff | 497.10 |
Domain Trusted Cutoff | 497.10 |
Noise Cutoff | 339.15 |
Domain Noise Cutoff | 339.15 |
Isology Type | subfamily |
HMM Length | 595 |
Author | Selengut J |
Entry Date | Aug 9 2002 3:35PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: PF00076) followed by a PABP-specific domain (PF00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm [3].
There are four paralogs in Homo sapiens which are expressed in testis (GP:11610605_PABP3 [1]), platelets (SP:Q13310_PABP4 [2]), broadly expressed (SP:P11940_PABP1 [3]) and of unknown tissue range (SP:Q15097_PABP2). |
References | RN [1]
RM PMID: 11328870
RT Human testis expresses a specific poly(A)-binding protein.
RA Feral C, Guellaen G, Pawlak A.
RL Nucleic Acids Res 2001 May 1;29(9):1872-1883
RN [2]
RM PMID:8524242
RT iPABP, an inducible poly(A)-binding protein detected in activated human T cells.
RA Yang H., Duckett C.S., Lindsten T.
RL Mol. Cell. Biol. 15:6770-6776(1995).
RN [3]
RM PMID:9582337
RT The human poly(A)-binding protein 1 shuttles between the nucleus and the cytoplasm.
RA Afonina E., Stauber R., Pavlakis G.N. |