| Accession | TIGR01530 |
| Name | nadN |
| Function | NAD nucleotidase |
| Gene Symbol | nadN |
| Trusted Cutoff | 436.00 |
| Domain Trusted Cutoff | 436.00 |
| Noise Cutoff | 253.50 |
| Domain Noise Cutoff | 253.50 |
| Isology Type | equivalog |
| EC Number | 3.1.3.5 3.6.1.22 |
| HMM Length | 550 |
| Mainrole Category | Transport and binding proteins |
| Subrole Category | Other |
| Gene Ontology Term | GO:0000210: NAD+ diphosphatase activity molecular_function |
| | GO:0008253: 5'-nucleotidase activity molecular_function |
| | GO:0019677: NAD catabolic process biological_process |
| | GO:0030288: outer membrane-bounded periplasmic space cellular_component |
| | GO:0051181: cofactor transport biological_process |
| Author | Haft DH |
| Entry Date | Jun 5 2002 11:36AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM describes NadN of Haemophilus influenzae and a small number of close homologs in pathogenic, Gram-negative bacteria. NadN is a periplasmic enzyme that cleaves NAD (nicotinamide adenine dinucleotide) to NMN (nicotinamide mononucleotide) and AMP. The NMN must be converted by a 5'-nucleotidase to nicotinamide riboside for import. NadN belongs a large family of 5'-nucleotidases and has NMN 5'-nucleotidase activity for NMN, AMP, etc. |
| References | RN [1]
RM 11395461
RT NadN and e (P4) are essential for utilization of NAD and nicotinamide mononucleotide but not nicotinamide riboside in Haemophilus influenzae.
RA Kemmer G, Reilly TJ, Schmidt-Brauns J, Zlotnik GW, Green BA, Fiske MJ, Herbert M, Kraiss A, Schlor S, Smith A, Reidl J.
RL J Bacteriol. 2001 Jul;183(13):3974-81. |
