Accession | TIGR01513 |
Name | NAPRTase_put |
Function | nicotinate phosphoribosyltransferase |
Gene Symbol | pncB |
Trusted Cutoff | 297.40 |
Domain Trusted Cutoff | 297.40 |
Noise Cutoff | 119.20 |
Domain Noise Cutoff | 119.20 |
Isology Type | hypoth_equivalog |
EC Number | 6.3.4.21 |
HMM Length | 452 |
Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
Subrole Category | Pyridine nucleotides |
Gene Ontology Term | GO:0004516: nicotinate phosphoribosyltransferase activity molecular_function |
| GO:0019357: nicotinate nucleotide biosynthetic process biological_process |
| GO:0019358: nicotinate nucleotide salvage biological_process |
Author | Haft DH |
Entry Date | May 20 2002 1:56PM |
Last Modified | Feb 25 2011 12:36PM |
Comment | A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This HMM represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life.
Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. |