| Accession | TIGR01472 |
| Name | gmd |
| Function | GDP-mannose 4,6-dehydratase |
| Gene Symbol | gmd |
| Trusted Cutoff | 415.00 |
| Domain Trusted Cutoff | 415.00 |
| Noise Cutoff | 103.25 |
| Domain Noise Cutoff | 103.25 |
| Isology Type | equivalog |
| EC Number | 4.2.1.47 |
| HMM Length | 342 |
| Mainrole Category | Cell envelope |
| Subrole Category | Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides |
| Gene Ontology Term | GO:0000271: polysaccharide biosynthetic process biological_process |
| | GO:0008446: GDP-mannose 4,6-dehydratase activity molecular_function |
| Author | Haft DH |
| Entry Date | Mar 18 2002 5:50PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Alternate name: GDP-D-mannose dehydratase. This enzyme converts GDP-mannose to GDP-4-dehydro-6-deoxy-D-mannose, the first of three steps for the conversion of GDP-mannose to GDP-fucose in animals, plants, and bacteria. In bacteria, GDP-L-fucose acts as a precursor of surface antigens such as the extracellular polysaccharide colanic acid of E. coli.
Excluded from this model are members of the clade that score poorly because of highly dervied (phylogenetically long-branch) sequences, e.g. Aneurinibacillus thermoaerophilus Gmd, described as a bifunctional GDP-mannose 4,6-dehydratase/GDP-6-deoxy-D-lyxo-4-hexulose reductase (PUBMED:11096116). |
| References | DR EXPERIMENTAL; SP|O60547; Homo sapiens
DR EXPERIMENTAL; OMNI|HP0044; Helicobacter pylori
DR EXPERIMENTAL; SP|P32054; Escherichia coli
DR EXPERIMENTAL; SP|Q9SNY3; Arabidopsis thaliana
RN [1]
RM 9525924
RT Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro.
RA Sullivan FX, Kumar R, Kriz R, Stahl M, Xu GY, Rouse J, Chang XJ, Boodhoo A, Potvin B, Cumming DA.
RL J Biol Chem 1998 Apr 3;273(14):8193-202 |
| Genome Property | GenProp0930: GDP-4-keto-6-deoxymannose biosynthesis from b-D-fructose-6-phosphate (HMM) |
