Accession | TIGR01428 |
Name | HAD_type_II |
Function | haloacid dehalogenase, type II |
Gene Symbol | dehII |
Trusted Cutoff | 125.40 |
Domain Trusted Cutoff | 125.40 |
Noise Cutoff | 72.30 |
Domain Noise Cutoff | 72.30 |
Isology Type | equivalog |
EC Number | 3.8.1.2 |
HMM Length | 197 |
Gene Ontology Term | GO:0006805: xenobiotic metabolic process biological_process |
| GO:0018784: (S)-2-haloacid dehalogenase activity molecular_function |
Author | Selengut J |
Entry Date | Feb 1 2002 11:59AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | Catalyzes the hydrolytic dehalogenation of small L-2-haloalkanoic acids to yield the corresponding D-2-hydroxyalkanoic acids.
Belongs to the Haloacid Dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases (PF00702), class (subfamily) I.
Note that the Type I HAD enzymes have not yet been fully characterized, but clearly utilize a substantially different catalytic mechanism and are thus unlikely to be related. |
References | RN [1]
RM 1744048
RT Characterization of the haloacid dehalogenase from Xanthobacter autotrophicus GJ10 and sequencing of the dhlB gene
RA van der Ploeg J, van Hall G, Janssen DB
RL J Bacteriol 1991 Dec;173(24):7925-33
RN [2]
RM 10498712
RT Cloning and characterization of a cryptic haloacid dehalogenase from Burkholderia cepacia MBA4
RA Tsang JS, Sam L
RL J Bacteriol 1999 Oct;181(19):6003-9
RN [3]
RM 10198020
RT nvestigation of two evolutionarily unrelated halocarboxylic acid dehalogenase gene families
RA Hill KE, Marchesi JR, Weightman AJ
RL J Bacteriol 1999 Apr;181(8):2535-47
RN [4]
RM 11404103
RT Microbial dehalogenation
RA Janssen DB, Oppentocht JE, Poelarends GJ
RL Curr Opin Biotechnol 2001 Jun;12(3):254-8
DR PFAM; PF00702; hydrolase
DR EXPERIMENTAL; GP|4127501; cryptic, not expressed by all individuals in a culture; Burkholderia cepacia MBA4
DR EXPERIMENTAL; GP|4468659; Pseudomonas putida PP3 |