Accession | TIGR01424 |
Name | gluta_reduc_2 |
Function | glutathione-disulfide reductase |
Gene Symbol | gor |
Trusted Cutoff | 606.05 |
Domain Trusted Cutoff | 606.05 |
Noise Cutoff | 494.95 |
Domain Noise Cutoff | 494.95 |
Isology Type | equivalog |
EC Number | 1.8.1.7 |
HMM Length | 446 |
Mainrole Category | Energy metabolism |
Subrole Category | Electron transport |
Gene Ontology Term | GO:0004362: glutathione-disulfide reductase activity molecular_function |
| GO:0030503: regulation of cell redox homeostasis biological_process |
| GO:0055114: oxidation-reduction process biological_process |
Author | Haft DH |
Entry Date | Jan 28 2002 1:21PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | The tripeptide glutathione is an important reductant, e.g., for maintaining the cellular thiol/disulfide status and for protecting against reactive oxygen species such as hydrogen peroxide. Glutathione-disulfide reductase regenerates reduced glutathione from oxidized glutathione (glutathione disulfide) + NADPH. This HMM represents one of two closely related subfamilies of glutathione-disulfide reductase. Both are closely related to trypanothione reductase, and separate models are built so each of the three can describe proteins with conserved function. This model describes glutathione-disulfide reductases of plants and some bacteria, including cyanobacteria. |