Accession | TIGR01353 |
Name | dGTP_triPase |
Function | putative dGTPase |
Gene Symbol | dgt |
Trusted Cutoff | 152.35 |
Domain Trusted Cutoff | 152.35 |
Noise Cutoff | 116.90 |
Domain Noise Cutoff | 116.90 |
Isology Type | subfamily |
EC Number | 3.1.5.1 |
HMM Length | 389 |
Mainrole Category | Purines, pyrimidines, nucleosides, and nucleotides |
Subrole Category | Nucleotide and nucleoside interconversions |
Gene Ontology Term | GO:0008832: dGTPase activity molecular_function |
| GO:0015949: nucleobase-containing small molecule interconversion biological_process |
Author | Haft DH |
Entry Date | Oct 4 2001 1:39PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | dGTP triphosphohydrolase (dgt) releases inorganic triphosphate, an unusual activity reaction product, from GTP. Its activity has been called limited to the Enterobacteriaceae, although homologous sequences are detected elsewhere. This finding casts doubt on whether the activity is shared in other species. In several of these other species, the homologous gene is found in an apparent operon with dnaG, the DNA primase gene. The enzyme from E. coli was shown to bind coopertatively to single stranded DNA. The biological role of dgt is unknown. |
References | DR EXPERIMENTAL; SP|P15723; Escherichia coli
DR EXPERIMENTAL; SP|Q59827; Shigella boydii
RM 9422594
RT Characterization of the dnaG locus in Mycobacterium smegmatis reveals linkage of DNA replication and cell division.
RA Klann AG, Belanger AE, Abanes-De Mello A, Lee JY, Hatfull GF.
RL J Bacteriol 1998 Jan;180(1):65-72
DR HAMAP; MF_01213; 6 of 6 |